NEW Azelaic Brightening Serum

Friday, March 4, 2016 - 9:53am

Introducing Azelaic Brightening Serum

 

Azelaic acid is a natural material produced by a yeast that lives on normal skin, Malassezia furfur (also known as Pityrosporum ovale) and is also found in other sources, including wheat, rye and barley. Azelaic Acid is also effective in treating a number of skin conditions, such as acne, inflammation and hyperpigmentation. It acts has a melanogenesis inhibitor that supresses tyrosinase production and aslo kills malfunctioning melanocytes without injuring healthy surrounding cells. This ingredient also provides bactericidal and antimicrobial action and helps to normalize keratinization in the skin.

Azelaic Acid and Acne

  • Slows the growth and eventually helps kill the 2 bacterias that can reside on the skin surface that lead to acne (Propionibacteria acnes and Staphylococcus epidermis).
  • Improves blocked pores by decreasing the production of dead skin cells (keratin).
  • Slow the production of abnormal melanocytes (the pigment producing cells), thus helping to minimize unwanted discoloration.

 

Azelaic Acid and Rosacea

  • Decreased the KLK5 protein in the human keratinocytes treated in culture and was shown to suppress KLK5 protein production in differentiated and undifferentiated human keratinocyte cells.
  • Lower concentrations of AzA interferes in the post-transcriptional regulation of KLK5 that could suppress the gene expression of cAMP, KLK5 and TLR2. According to Dr. Gallo, the downregulation possibly contributes to AzA's anti-inflammatory mechanism of action.

Induced downregulation of TLR (toll-like receptor) may in turn downregulate cathelicidins that are typically at higher levels in rosacea-affected skin. This suggests that AzA can specifically target rosacea-generating proteins, resulting in an improvement of the signs and symptoms of the disease.

 

Azelaic Acid and Hyperpigmentation

  • Suppresses the proliferation of abnormal melanin producing cells (melanocytes), apparently by reducing the rate of DNA synthesis and mitochondrial enzymes, thereby inducing direct cytotoxic effects toward the melanocyte.
  • A more attractive skin lightening alternative for melasma and some other hyperpigmentation disorders. However, as opposed to hydroquinone, azelaic acid is not very effective against freckles and age spots as its much more active against hyperpigmentation caused by abnormal melanin synthesis, which makes it an ideal choice when you’re looking to get rid of hyper-pigmentation disorders.

In a 24-week study in South America found that a 20% concentration of azelaic acid was equivalent to 2% hydroquinone in the treatment of melasma, whereas another study conducted in the Philippines found that 20% azelaic acid was superior to 2% hydroquinone.

 

Skin Tip: Always top these corrective products like Azelaic Brightening Serum with a UVA/UVB broadspectrum sunscreen. It’s important to shielding your skin from all wavelengths of UVR light, even those emitted by computer screens and fluorescent bulbs, which have been shown to bring on brown spots.

 

 

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