Proven by Science: Skin Care Ingredients that Work - Ingredient #1

Thursday, October 10, 2013 - 11:13pm


What it is?

Niacinamide - also known as vitamin B3 - is a water soluble vitamin that can be applied topically

What is does?

Niacinamide is a skin care multi-tasker in every sense of the word. It has demonstrated occlusive benefits and helps reduce trans-epidermal water loss and improve the moisture content of the skin. These benefits also increase skin barrier function, making it more resilient against irritants. What's more, it has the ability to reduce redness and inflammation associated with acne, rosacea, psoriasis and pigment problems and it's safe for use on sensitive skin.

Supporting Evidence

In a clinical study that evaluated topical niacinamide (4%) in the treatment of melasma versus hydroquinone (4%),  results showed it decreased pigmentation due to its anti-inflammatory properties. While niacinamide's success at reducing the appearance of melasma was slightly below HQ, patients using it showed "no significant side effects" and it was reported as being "well tolerated", meaning the ingredient could be used for longer periods.


Citation: J. Navarrete-Solis, J.P. Catanedo-Cazares et al. (2011) "A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in Treatment of Melasma, " Dermatology Research and Practice, vol. 2011.


Featured Products with Niacinamide:

  • EltaMD Clear
  • PCA SKIN Clearskin
  • PCA SKIN Hydrating Serum
  • PCA SKIN Pigment Bar
  • EltaMD AM Therapy
  • Stemulation Boost Creme
  • Circadia Daytime Control

"PCA SKIN Clearskin contains therapeutic levels of niacinamide (4%), which is proven to provide antioxidant protection and decrease erythema, blotchiness, the appearance of fine lines and wrinkles, and hyperpigmentation." - Dr. Jennifer Linder, Chief Scientific Officer, PCA SKIN


Citation: Fowler, J.F., MD, Wooley-Llyod, H., MD, Waldorf, H., MD, and Saini, R., MD (2010) "Innovations in Natural Ingredients and their Use in Skin Care." Journal of Drugs in Dermatology, 9.6: 72-81. Print.





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